The American Institute for Manufacturing Integrated Photonics (AIM Photonics) is a public-private partnership established to develop US manufacturing capability in photonics. This talk will detail progress in demonstrating AIM Photonics’ fabrication capabilities in biological sensing, including silicon nitride ring resonators and strategies for on-chip spectrometers.
Most of the brain’s energy budget is consumed by neurons for synaptic transmission, but the mechanisms underlying energy usage is poorly understood. We use genetically encoded biosensors in situ to measure energy regulation at synapses to understand how neurons efficiently use energy for synaptic transmission.
We developed a label-free biosensor for the detection of single nucleotide polymorphisms based on dielectrophoresis. We demonstrate that this method can identify the last nucleotide in a single-strand DNA with ten nucleotides.
To address critical issues with microRNA detection, we have developed a new method where we used molecular-field interactions to concentrate target miRNA near micro-electrodes in the disposable device followed by electrical impedance to quantify the target miRNAs.
We demonstrate a rapid and label-free method to detect the concentration of the messenger RNA of proteins from living cells that can be used in the identification of cancer cells by combining dielelectrophoresis and image processing.
Inhalation of IPA impairs cognition and depresses the nervous system. Current gas-phase sensors are unable to selectively detect isopropyl alcohol from other volatile organic compounds. We present the development of bioinspired sensors using nanomaterials to provide real-time monitoring and differentiate IPA from background compounds.