H. Schmidt (US) University of California, Santa Cruz
University of California, Santa CruzAuthor Of 4 Presentations
MB4.3 - MULTIPLEXED DETECTION OF SINGLE ANTIBIOTIC DRUG-RESISTANT PLASMIDS USING MULTIMODE INTERFERENCE WAVEGUIDE BASED OPTOFLUIDIC CHIP
- G. Gopalakrishnan Meena (US) University of California Santa Cruz
- O. Brown (US) Brigham Young University
- R. Hanson (US) Brigham Young University
- R. Wood (US) Brigham Young University
- W. Pitt (US) Brigham Young University
- A. Woolley (US) Brigham Young University
- R. Robison (US) Brigham Young University
- A. Hawkins (US) ECEn Department, Brigham Young University, 459 Clyde Building
- H. Schmidt (US) University of California, Santa Cruz
Abstract
Abstract
A single multimode interference waveguide is used to create distinct spectral spot patterns on two liquid-core waveguides on an optofluidic chip. This device is used for multiplexed detection of antibiotic-resistant plasmids with single nucleic acid sensitivity.
MH4.2 - THREE-DIMENSIONAL HYDRODYNAMIC FOCUSING DESIGNS FOR INTEGRATED OPTOFLUIDIC DETECTION ENHANCEMENT
Abstract
Abstract
Three-dimensional hydrodynamic focusing promises to enhance detection capabilities of optofluidic sensors, enabling low concentration interrogation with higher confidence, critical for disease diagnosis. Novel 3DHDF designs with optofluidic channel diameters in the range of ten microns are evaluated, predicting detection enhancement of up to 3.54 times.
MH4.3 - FREE SPACE EXCITATION IN OPTOFLUIDIC DEVICES FOR SINGLE PARTICLE DETECTION
- M. Amin (US) School of Engineering, University of California, Santa Cruz, 1156 High Street
- M. Hamblin (US) ECEn Department, Brigham Young University
- G. Meena (US) School of Engineering, University of California, Santa Cruz, 1156 High Street
- A. Hawkins (US) ECEn Department, Brigham Young University, 459 Clyde Building
- H. Schmidt (US) University of California, Santa Cruz
Abstract
Abstract
Free space top-down illumination of liquid-core waveguides in an optofluidic chip is implemented by milling slits into a metal layer covering the waveguide channel. Detection of single microbeads with excellent signal-to-noise ratio is demonstrated for different milling depths.