A 3-D subnanometer vibrometry system based on Optical Coherence Tomography (OCT) is proposed in this work to measure the vector motion of a sample as well as the structure, which cannot be achieved by a current OCT based vibrometry system that measure 1-D vibrations only.
Measuring depth-resolved birefringence traditionally requires at least two distinct input polarization states. We identified a constraint on the evolution of the polarization state as a function of the round-trip path-length into birefringent tissue that enables to recover comparable results using only a single input state.
Methylene Blue (MB), an FDA approved dye, has been widely used in clinical applications. However, issues remain for its use as contrast agent: production of 1O2, reduction into leuco-MB, and nonspecific tagging. These issues were addressed by loading MB into Poly-Lactic-co-Glycolic Acid (PLGA) particles.
We introduce and apply spatiotemporal optical coherence (STOC) manipulation to full-field swept-source optical coherence tomography. We present imaging of the 1951 USAF resolution test chart covered by the rat skin ex vivo. Then we show aberration suppression using STOC enhanced by numerical phase correction.