Photodynamic therapy (PDT, Light based therapeutic modality) showed promise for oral cancer treatment with excellent healing of mucosa. To enable PDT in low-resource settings, battery-powered light source coupled with fiber delivery and oral applicators was developed and evaluated in pilot clinical study.
We describe the development of multimodal probes capable of acquiring fluorescence and optical coherence tomography signals through a single fiber. We demonstrate their use by ex vivo imaging genetically-modified cells expressing a fluorescent protein, allowing their distribution to be visually assessed within the airway.
We have developed a scanless confocal microscope and demonstrated high-speed cellular imaging of the human skin in vivo. Using the high imaging speed of 203 frames/sec, rapid blood flow was well visualized.