MH4.1 - PHOTONIC RESONATOR HYBRIDS FOR ULTRASENSITIVE LIQUID BIOPSY OF NUCLEIC ACID BIOMARKERS FOR CANCER
- B. Cunningham (US) University of Illinois at Urbana-Champaign
- T. Canady (US) University of Illinois at Urbana-Champaign
- N. Li (US) university of Illinois at Urbana-Champaign
- Q. Huang (US) University of Illinois at Urbana-Champaign
- Y. Lu (US) University of Illinois at Urbana-Champaign
- M. Kohli (US) Moffitt Cancer Center
Abstract
Abstract
We demonstrate Photonic Resonator Absorption Microscopy in which plasmonic nanoparticles are easily detected through hybrid resonant coupling when attached to a photonic crystal. The approach is used to detect miRNA cancer biomarkers with digital precision and 100 aM detection limits.
MH4.2 - THREE-DIMENSIONAL HYDRODYNAMIC FOCUSING DESIGNS FOR INTEGRATED OPTOFLUIDIC DETECTION ENHANCEMENT
Abstract
Abstract
Three-dimensional hydrodynamic focusing promises to enhance detection capabilities of optofluidic sensors, enabling low concentration interrogation with higher confidence, critical for disease diagnosis. Novel 3DHDF designs with optofluidic channel diameters in the range of ten microns are evaluated, predicting detection enhancement of up to 3.54 times.
MH4.3 - FREE SPACE EXCITATION IN OPTOFLUIDIC DEVICES FOR SINGLE PARTICLE DETECTION
- M. Amin (US) School of Engineering, University of California, Santa Cruz, 1156 High Street
- M. Hamblin (US) ECEn Department, Brigham Young University
- G. Meena (US) School of Engineering, University of California, Santa Cruz, 1156 High Street
- A. Hawkins (US) ECEn Department, Brigham Young University, 459 Clyde Building
- H. Schmidt (US) University of California, Santa Cruz
Abstract
Abstract
Free space top-down illumination of liquid-core waveguides in an optofluidic chip is implemented by milling slits into a metal layer covering the waveguide channel. Detection of single microbeads with excellent signal-to-noise ratio is demonstrated for different milling depths.