Abstract

Biosensors incorporating optofluidic waveguides take advantage of a full suite of integrated optical structures. Compatible with visible wavelengths, these labs-on-chip are constructed primarily from silica films on silicon substrates and include optimized liquid core, buried rib, and multi-mode-interference (MMI) waveguides.

Abstract

I will discuss applications of a waveguide-based chip-scale platform for ultrasensitive biomolecule analysis. Examples include amplification-free detection of nucleic acids, multiplex detection of single viruses using MMI waveguides, simultaneous detection of proteins and nucleic acid biomarkers, and integration of nanopores for electro-optical single molecule analysis.

Abstract

Combining light and sound, photoacoustic imaging (PAI) is a powerful tool for anatomical, functional, and molecular imaging. We are pioneering in multiple PAI new technologies that have collectively enabled miniaturized, deep, and high-sensitivity biomedical applications in drug screening, early cancer detection, and neuronal activity imaging.