Catheter Ablation -> Atrial Fibrillation & Atrial Flutter: -> Clinical Trials / Outcomes D-PO01 - Featured Poster Session (ID 11) Poster

D-PO01-169 - Atrial Fibrillation Complexity Score Predicts Patient Outcome After Pulmonary Vein Ablation (ID 948)

Abstract

Background: Atrial Fibrillation (AF) clinical evaluation (i.e. paroxysmal vs. persistent) remains inaccurate to stratify patient’s outcome to predict ablation outcome.
Objective: We developed a new score based on electrophysiological variables obtained during noninvasive electrocardiographic imaging (ECGi) to stratify patients undergoing AF ablation.
Methods: Thirty AF patients were included (17 paroxysmal, 61±14 yrs, 22 (66%) female). All patients underwent circumferential pulmonary vein ablation for clinical indication and were evaluated six months after the procedure. Both clinical variables and and ECGi data obtained prior to ablation were included in the study. We analyzed ECGi recordings, including Dominant Frequency (DF), Rotor Dynamics and Entropy in order to calculate a new C-Score that described AF complexity. We developed a regression algorithm that was applied to identify variables that better explained 6-month outcome of patients following ablation.
Results: Eighteen (60%) patients were in sinus rhythm at the end of follow-up. C-Score resulted in higher values for those patients with AF recurrence after 6 months. The mean C-score of patients with recurrent AF after ablation was three times higher than patients that remained in sinus rhythm. Furthermore, C-score showed a sensitivity and specificity of 0.86 and 1, respectively, performing better than clinical classification (paroxysmal vs. persistent) with sensitivity and specificity 0.73 and 0.67, respectively.
Conclusion: The C-Score was able to predict the long-term outcome of patients undergoing AF ablation and may increase the stratification process of patients undergoing AF ablation.
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