Clinical Electrophysiology -> SVT/AVNRT/WPW/AT: -> Epidemiology of Cardiac Arrhythmias/ Epidemiology D-MP09 - Atrial Fibrillation: From Pathophysiology to Epidemiology to Treatment Options (ID 36) Moderated ePoster

D-MP09-03 - Atrial Fibrillation And The Risk Of Presenile Dementia In The General Population: Data From A Population-based Cohort (ID 845)


Background: Atrial fibrillation (AF) is considered a risk factor for dementia. However, the association between the two diseases is not well identified in different age subgroups.
Objective: This study aimed to determine the effect of AF and oral anticoagulant (OAC) on the risk of dementia development in different age subgroups using a longitudinal, population-based, and stroke-free cohort from the general population.
Methods: The association of incident AF with the incidence of dementia was assessed from January 1, 2005, to December 31, 2013, in 428,262 participants without a history of dementia or stroke from the Korea National Health Insurance Service-Health Screening cohort.
Results: Incident AF was observed in 10,983 participants. During the follow-up period, the incidence of dementia was 11.3 and 3.0 per 1000 person-years in the incident AF and AF-free groups, respectively. After adjustment for clinical variables, the risk of dementia was significantly increased by incident AF with a hazard ratio (HR) of 1.98 (95% confidence interval [CI]: 1.80-2.17, p<0.001), even after censoring for stroke (HR: 1.75, 95% CI: 1.56-1.97, p<0.001). The risk of presenile and senile dementia was increased by incident AF (Table). Younger participants with AF were prone to dementia development than older participants with AF (p for trend<0.001). OAC use was associated with a reduced risk of dementia (HR: 0.64, 95% CI: 0.49-0.84, p<0.001).
Conclusion: Younger participants with AF were prone to dementia development than older participants. And incident AF was associated with an increased risk of presenile dementia, independent of clinical stroke. OAC use was linked with a decreased incidence of dementia.
Incidences of dementia after censoring stroke during follow-up periods according to AF status.
Cases, No. (%)IncidenceAdjusted HR (95% CI)
Overall dementia
No AF (n=417,279)8,246 (2.0)2.71.00 (Reference)
AF (n=10,983)680 (6.2)9.11.75 (1.56-1.97)
Presenile dementia
No AF (n=409,145)902 (0.2)0.31.00 (Reference)
AF (n=10,177)53 (0.5)0.72.91 (1.93-4.41)
Senile dementia
No AF (n=416,241)7,344 (1.8)2.41.00 (Reference)
AF (n=10,909)627 (5.7)8.41.67 (1.49-1.87)