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D-WEP-04 - Bioresorbable Wireless Battery-free Pacemaker And Bioadhesive System For Electrical Stimulation Of The Heart (ID 823)


Background: Temporary pacemakers provide short-term cardiac pacing as a bridge to therapy or following cardiac surgery. A bioresorbable pacemaker can deliver electrotherapy and address infection, pathological tissue reaction, and re-operation for device removal.
Objective: To demonstrate the feasibility of a fully bioresorbable battery-free pacemaker and bioadhesive system for temporary pacemaking (A-C).
Methods: Pacing capabilities of the device were confirmed by far-field ECG recordings and optical mapping of ex vivo mouse, rabbit, and human cardiac tissue. Long-term pacing was verified by implanting the device into rats using suture (n = 19, G) or an electrically conductive bioresorbable adhesive (n = 22) and monitored daily via ECG. Pacing in fully conscious, freely moving animals was confirmed by ECG.
Results: In mouse, rabbit, and human ventricular slices, ECG or optical action potential traces show ventricular activation synchronous with the delivered electrical stimuli and the membrane potential activation originating from the site of electrode pad (D-F). For chronic pacing, the device can pace the heart for 26 days (H). Implantation with bioadhesive (I) showed continuous pacing for 8 days and showed less damage to tissue than suture (J). Animals implanted with devices can be paced tether-free while fully conscious and freely moving (K).
Conclusion: The bioresorbable pacemaker and adhesive system is fully implantable and can acutely and chronically capture the heart. This system serves as the basis for an alternative for temporary pacemakers.$$graphic_{4A0424AC-A572-4BE1-ACDF-9046E5DEE280}$$