Clinical Electrophysiology -> Ventricular Arrhythmias -> Mapping & Imaging D-AB10 - Ventricular Arrhythmias from Mechanism to New Ablation Targets (ID 52) Abstract Plus

D-AB10-06 - Global Three Dimensional Electroanatomic Mapping Of The Ventricular Epicardium (ID 738)

 T. Pong: Nothing relevant to disclose.


Background: The localization of ventricular tachycardia sources responsible for erratic electrical signaling can be facilitated by high-resolution epicardial mapping. Here, we describe an approach for rapid prototyping of patient-specific electrode mapping arrays via 3D printing. We demonstrate the use of this approach to perform high-resolution epicardial mapping in a porcine model of myocardial infarction and report on the global capture of premature ventricular complexes in vivo.
Objective: To perform high-resolution, epicardium-specific, global electrophysiological characterization of the right and left ventricle.
Methods: Three-dimensional surface profiles of the left and right ventricle were generated from non-invasive MRI imaging followed by the design and creation of 3D printed epicardial shells. Electrograms were recorded with gold-plated electrodes in adult and piglet swine via sternotomy. Electroanatomic maps were obtained 1) during sinus rhythm, 2) after ligation of the left anterior descending artery, and 3) during ectopic premature ventricular complexes.
Results: We demonstrate the use of 3D-printed anatomical models to perform global electroanatomic mapping of the right and left ventricle. Patient specific electrode arrays facilitate high spatial-temporal measurement of electrophysiological data in vivo and are capable of identify sites of origin of premature ventricular complexes.
Conclusion: Here we report on flexible electrode mapping arrays shaped to match the epicardial contours of the left and right ventricle. 3D printed geometries serve as a platform for flexible printed electrode arrays to capture high spatiotemporal resolution electrophysiological signals. In vivo physiological experiments demonstrate beat-to-beat global capture of premature ventricular complexes.