Catheter Ablation -> Atrial Fibrillation & Atrial Flutter: -> Experimental methods D-PO04 - Poster Session IV (ID 15) Poster

D-PO04-148 - Lesion Characteristics And Adjacent Tissue Damage Assessment With High Power And Short Duration Ablation: Comparison To Conventional Radiofrequency Ablation Power Setting (ID 466)


Background: There is increased interest in creating high-power short duration (HPSD) atrial ablation lesions in the field of AF ablation.
Objective: The purpose of the study was to evaluate lesion characteristics using two separate ablation protocols setting (HPSD: 50w/7seconds vs Control: 25W/30seconds).
Methods: Sixteen freshly killed porcine hearts were obtained, and the atrium and ventricle slabs were harvested for ablation. The each slabs were placed in a tissue bath with circulating 0.9% NaCl at maintained temperature 37℃ (Figure A). RFA with 4mm tip irrigated, force sensing catheter was performed. All lesions were ablated under recording the electrical parameters using with Ensite Navx system. To investigate the lesion characteristics, 20 lesions were made for each ablations protocol. Furthermore, to assess the adjacent tissue damage, the RFA was performed with the ventricle tissues were placed under the atrium tissue (Figure B; 15 lesions for each).
Results: Ablation parameters were similar between two groups (HPSD vs Control:impedance drop(Ω) 30.2±5.4 vs 33.6±7.8 P=0.18, contact force(g) 16.4±6.7 vs 14.2±2.7, P=0.12, LSI 5.24±0.6 vs 5.31±0.6 P=0.61).The lesion volume was similar and the lesion characteristics with HPSD were wider and shallower (Figure C; volume 22.6±8.4 mm3 vs 24.8±8.6 mm3 P=0.48, diameter 4.21±0.6mm vs 3.86±0.6mm P=0.15, depth 1.67±0.5mm vs 2.17±0.8mm P=0.06). The adjacent tissue damages were less seen in HPSD group (Figure D; 0/15 (0%) vs 3/15 (20%), P=0.034)
Conclusion: Effective lesions were made with HPSD, thereby reducing RFA procedure time. Although the lesion volume were similar between 2 groups, collateral damage were less seen in HPSD group.