Catheter Ablation -> Atrial Fibrillation & Atrial Flutter: -> Clinical Trials / Outcomes
D-PO04 - Poster Session IV (ID 15)
Poster
D-PO04-139 - Clinical Risk Factors Of Mortality For Atrial Fibrillation Patients After Receiving Catheter Ablation: A 10-year Cohort Study (ID 460)
Abstract
Background: Catheter ablation (CA) in atrial fibrillation (AF) patients had a significant benefit for cardiovascular outcomes. However, death risks in AF CA patients remain unclear.
Objective: This study aimed to explore the clinical risk factors of mortality in AF patients with ablation.
Methods: Enrolled were 1881 consecutive patients undergoing AF CA (group 1) and 787 AF patients without AF CA (Group 2) in a medical center, and 787 controls without AF. We evaluated the death rates linked to the Taiwan Death Registry. Significant risk factors of death were selected via a Cox regression model. A risk factor with a P-value<0.2 in the univariate model was selected into a multivariate model.
Results: Group 1 (55.4±11.4 years, 72.6% males) had a better event free survival rate of deaths than Group 2 (54.9±11.6 years, 70% males), and Group 1 benefited from reduced risks for cardiovascular outcomes than Group 2 (Figure). During a median 6 year follow-up, 70 Group 1 patients died (3.7 %) at an average duration of 5.5 and 6 years for cardiovascular deaths (CVD) and total mortality (1.7 and 5.78/1000 person-years), respectively. On the other hand, 120 Group 2 patients died (37.6%, incidence rates of CVD and total mortality of 18.1 and 44.6/1000 person-years, respectively). A multivariate analysis indicated that an older age (HR: 1.16, 95% CI: 1.06-1.27; cut-off point >64.5 years) and diabetes mellitus (HR: 2.20, 95% CI: 1.01-4.77) independently predicted mortality events.
Conclusion: Ablation produced a significant reduction in cardiovascular outcomes during long-term follow-up. Aging and diabetes mellitus significantly increased the mortality risk in AF patients receiving CA regardless of the AF type.
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Objective: This study aimed to explore the clinical risk factors of mortality in AF patients with ablation.
Methods: Enrolled were 1881 consecutive patients undergoing AF CA (group 1) and 787 AF patients without AF CA (Group 2) in a medical center, and 787 controls without AF. We evaluated the death rates linked to the Taiwan Death Registry. Significant risk factors of death were selected via a Cox regression model. A risk factor with a P-value<0.2 in the univariate model was selected into a multivariate model.
Results: Group 1 (55.4±11.4 years, 72.6% males) had a better event free survival rate of deaths than Group 2 (54.9±11.6 years, 70% males), and Group 1 benefited from reduced risks for cardiovascular outcomes than Group 2 (Figure). During a median 6 year follow-up, 70 Group 1 patients died (3.7 %) at an average duration of 5.5 and 6 years for cardiovascular deaths (CVD) and total mortality (1.7 and 5.78/1000 person-years), respectively. On the other hand, 120 Group 2 patients died (37.6%, incidence rates of CVD and total mortality of 18.1 and 44.6/1000 person-years, respectively). A multivariate analysis indicated that an older age (HR: 1.16, 95% CI: 1.06-1.27; cut-off point >64.5 years) and diabetes mellitus (HR: 2.20, 95% CI: 1.01-4.77) independently predicted mortality events.
Conclusion: Ablation produced a significant reduction in cardiovascular outcomes during long-term follow-up. Aging and diabetes mellitus significantly increased the mortality risk in AF patients receiving CA regardless of the AF type.
