Catheter Ablation -> Atrial Fibrillation & Atrial Flutter: -> Clinical Trials / Outcomes D-PO03 - Poster Session III (ID 48) Poster

D-PO03-186 - Impact Of Obstructive Sleep Apnea On Recurrence Rates Following Paroxysmal And Persistent Atrial Fibrillation Ablation (ID 356)

Abstract

Background: Obstructive sleep apnea (OSA) has been associated with increased rate of atrial fibrillation (AF) recurrence following ablation. However the impact of AF type on this association is not well defined.
Objective: Assess the effect of OSA on ablation outcomes based on AF type.
Methods: We performed a retrospective study of patients who underwent AF ablation at the Veterans Affairs health care system between 2013 and 2017. Only the first reported ablation procedure was included. Patients were divided into two groups based on the presence or absence of OSA diagnoses at time of ablation. Patients were stratified based on AF type. Propensity-score matched analysis was then used to balance for baseline characteristics.
Results: The matched cohort has 2 groups with 332 patients in each one (219 paroxysmal, 113 persistent), 97% males, 92% Caucasians and mean age 63.9 ± 8.1 years and mean follow up 40.1 ± 12.9 months. All-cause mortality was not statistically different between OSA vs non-OSA groups (4.8% vs 7.8%, HR 0.63, 95% CI 0.34-1.18, p 0.15). On the other hand, OSA group was associated with higher incidence of AF recurrence after ablation when compared to non-OSA group (52.7% vs 41.6%, HR 1.4, 95% CI 1.16-1.81, p <0.01). When patients were stratified based on AF type, the same trend was seen in paroxysmal AF stratum (46.6% vs 39.7%, HR 1.3, 95% CI 1.01-1.79, p 0.04, OSA vs non-OSA groups respectively) and persistent AF stratum (64.6% vs 45.1%, HR 1.63, 95% CI 1.14-2.33, p <0.01, OSA vs non-OSA groups respectively).
Conclusion: OSA is associated with higher rates of AF recurrence following ablation regardless of the AF type. However this impact tends to be stronger in persistent AF.

Collapse