Allied Professionals (Non-physician submissions only) -> Clinical Research D-MP03 - From Patients to Procedures: The Spectrum of Care (ID 23) Moderated ePoster

D-MP03-02 - Are There Differences Between Genders Undertaking Risk Factor Modification? (ID 32)


Background: Risk factor modification improves outcomes for patients with atrial fibrillation (AF). However, whether there is a difference in benefits between genders has not been characterized.
Objective: We aimed to assess the difference between men and women undergoing risk factor modification.
Methods: Of 1415 consecutive patients referred for electrophysiology management of AF, 825 had BMI≥27 kg/m2 and were offered weight management. After screening for exclusion criteria, 355 were included in this analysis. Patients were divided into gender (Male: 234, Female: 121) to undertake analysis.
Results: Females were significantly older (68±10 v 61±10, p<0.001) with greater BMI (34.3±5.5 v 32.7±4.0, p=0.009) and normalized cardiorespiratory fitness (97±35 v 85±18%, p=0.001) compared to male patients. Notably, females were more likely to have paroxysmal AF compared to males (53.5% v 30%, p<0.001) yet were equally symptomatic. The mean number of anti-arrhythmics was reduced from baseline to follow-up with no significant effect of gender (p=0.092). There was no difference between genders in requirement for catheter ablation. There was similar risk factor clinic attendance between genders (Males 58.7%, Females 60%, p=0.82). Gender was not a significant predictor of weight-loss or fitness gain (p>0.05). With every 1-Kg weight-loss, there was a significant reduction in AF recurrence for both males (HR: 0.97, 95% CI: 0.95-0.99) and females (HR 0.97, 95% CI: 0.95-1.0). Weight-loss was a significant predictor of AF symptom improvement (p<0.001), with no effect of gender (p=0.88). For fitness improvement, the benefits of each 1-MET gain on AF recurrence were similar for both genders (Male: HR 0.86, 95% CI 0.77-0.95; Female: HR 0.83, 95% CI 0.71-0.96).
Conclusion: Despite gender differences at baseline with regards to AF type, age, BMI and cardiorespiratory fitness, the benefits of weight loss and fitness gain are equally favorable for both men and women. This study reinforces the need to address lifestyle risk factors to minimize arrhythmia recurrence and reduce symptom severity for all individuals.