Clinical Electrophysiology -> Atrial Fibrillation & Atrial Flutter: -> Physiology D-PO02 - Poster Session II (ID 47) Poster

D-PO02-234 - Body Composition, Physical Activity And Atrial Fibrillation Risk: Data From The Uk Biobank (ID 268)

Abstract

Background: Obesity increases the risk of atrial fibrillation (AF). However, whether risk is driven through fat mass, lean body mass, or both is unknown.
Objective: Amongst UK Biobank participants, we assessed the association of body mass index, fat mass and lean body mass with AF risk. Moreover, we sought to evaluate whether physical activity mediates the influence of either lean or fat mass on AF risk.
Methods: Anthropometric measures were assessed amongst 492,132 UK Biobank participants aged 40-69 years. Body composition analysis was performed using 8-electrode biompedance analysis. Body fat percentage was directly assessed, with fat mass and lean body mass subsequently computed. Physical activity was assessed using a validated questionnaire. AF incidence was identified through linkage to electronic medical records.
Results: There were 12933 AF events over 6.9±1.2 year follow-up. All anthropometric measures were associated with AF risk with evidence of non-linearity. High lean mass, remained significantly associated with AF, following adjustment for measures of adiposity (HR for 1 SD above mean 1.37, 95% CI: 1.32-1.43). Fat mass was significantly associated with AF risk after adjustment for lean mass (HR for 1 SD above mean 1.16, 95% CI: 1.11-1.20). We noted a significant interaction between lean mass and physical activity on AF risk. Greater physical activity was associated with lower AF risk only in the lower ranges of lean mass.
Conclusion: Both lean and fat mas are associated with AF risk, with a greater contribution of lean mass. Physical activity is associated with a lower AF risk only in participants across the lower ranges of lean body mass.

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