Policy, Payment & Practice -> Clinical Quality Measures and Outcomes D-PO02 - Poster Session II (ID 47) Poster

D-PO02-115 - Nationwide Study Of Sex Differences In Incident Heart Failure Hospitalizations Following Newly Diagnosed Atrial Fibrillation (ID 212)

 H. Yogasundaram: Nothing relevant to disclose.


Background: Non-valvular AF (NVAF) is a strong risk factor for heart failure (HF) and the presence of both conditions increases the risk of mortality. Data regarding sex differences for new HF without a prior history among incident AF patients is sparse.
Objective: To evaluate sex differences in new HF hospitalizations at 1-year following newly diagnosed NVAF.
Methods: Patients ≥20 years old who were hospitalized for incident NVAF in Canada (except Quebec) between April 1 2006 and March 31 2015 were identified (ICD-10 code I48) using a Canadian Institute of Health Information database. Patients with a history of NVAF or HF in the 2 years prior to study start were excluded. The primary outcome was new HF hospitalization 1-year following incident NVAF.
Results: There were 377,795 NVAF patients (54.6% women). Compared to men, women were older (80 vs 74 years), more likely to have a history of hypertension (44.0% vs 40.5%) and stroke/systemic embolism (10.8% vs 8.3%), and less likely to have diabetes (20.8% vs. 24.9%) and coronary artery disease (12.4% vs 23.2%; p<0.0001 for all comparisons). One-year following incident NVAF, women had higher rates of new HF hospitalizations (8.5% vs 7.4%, p<0.0001), which persisted over the study period. There was a positive linear relationship between CHA2DS2-VASc score and incidence of new HF (Figure 1, p<0.0001).
Conclusion: In this nationwide study, we found women with incident NVAF and no history of HF had higher rates of new HF hospitalizations compared to men. Regardless of sex, a new HF hospitalization increases with CHA2DS2-VASc score. Given the poor prognosis and economic burden of the two conditions, strategies aimed at prevention are needed.