Heart Failure -> Heart Failure Management: -> Clinical Trials D-AB29 - LVADs, Barostim and Pacing Issues in HF management (ID 3) Abstract Plus

D-AB29-03 - Impact Of Age, Gender And Race On Arrhythmias Outcomes In Patients With Continuous Flow Left Ventricular Assist Devices (ID 1472)

Abstract

Background: Arrhythmias are common in continuous flow left ventricular assist device (LVAD) recipients. The impact of age, gender and race on arrhythmia incidence and associated clinical outcomes is unclear.
Objective: This multicenter study evaluated the impact of age, gender and race on incidence of arrhythmias, ICD shocks and mortality in LVAD patients.
Methods: Analysis was done on 436 patients who underwent LVAD implant at 5 US centers from 2010 to 2015. The group was divided based on their age, gender and race. Incidence of post-LVAD atrial arrhythmias (PL-AA), ventricular arrhythmias (PL-VA) and ICD shocks were analyzed in these groups. Kaplan-Meier curves were used for survival analysis.
Results: Of 436 patients, 49% were ≤60 years in age, 79% were males and 65% were Caucasians. Incidence of PL-AA was higher in the >60 age group vs the ≤60 age group (62% vs 49%, p<0.01), but there was no difference in PL-VA and post-LVAD ICD shocks. Males had significantly higher incidence of PL-VA (61% vs 49%, p=0.04) and a trend towards higher ICD shocks compared to females but no gender differences were seen in incidence of PL-AA. Caucasians had similar incidence of PL-AA, PL-VA and ICD shocks vs the non-Caucasian group. Kaplan-Meier analysis showed similar survival between the groups depending on age (p=0.94) and gender (p=0.31) but Caucasians had lower survival as compared to the non-Caucasian group (p=0.006) [Figure 1].
Conclusion: Age>60 years was associated with higher incidence of PL-AA and male gender was associated with higher incidence of PL-VA. Race had no impact on incidence of PL-AA and PL-VA. Survival did not depend on age or gender but was lower in the Caucasian group.
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