Policy, Payment & Practice -> Reimbursement, Regulation and Health Policy D-PO06 - Poster Session VI (ID 26) Poster

D-PO06-069 - Association Between Change In The Number Of Metabolic Syndrome Components And Risk Of Incident Atrial Fibrillation A Nationwide Population-based Study (ID 1377)

 S. Lee: Nothing relevant to disclose.


Background: There is a paucity of information on whether the changes in metabolic syndrome (MetS) and the number of MetS components affect the risk of new-onset atrial fibrillation (AF).
Objective: We aimed to evaluate whether changes in the MetS status and components of MetS affect AF risk using data from a nationwide observational cohort.
Methods: A total of 7,565,531 adults without prevalent AF (≥ 20-year-old, mean age 48±14 years), who underwent two serial health examinations from 2009 to 2012 by the Korean National Health Insurance Cooperation were identified. Incident AF was followed up till December 2017. We evaluated the risk of AF according to changes in MetS status and the number of MetS components in serial evaluations.
Results: During a mean 8-year follow-up, incident AF was diagnosed in 139,305 patients. After multivariable adjustment, the AF risk was higher by 31% in the persistent MetS group compared to the healthy subjects. Regardless of the MetS component type, the AF risk correlated with changes in the number of components. When patients had two, three, and four MetS components at the second examination, the AF risk was higher by 16%, 32%, and 47%, respectively, compared to those maintaining one or fewer components. The AF risk became higher as the number of components increased, and the AF risk became lower as the number of components decreased compared to those who maintained their MetS component number(s) in the follow-up examination (Figure).
Conclusion: The risk of AF showed association with the dynamic change of MetS status. Moreover, the AF risk became higher as the number of MetS components increased and became lower as the number of MetS components decreased.