Policy, Payment & Practice -> Health Economics D-PO05 - Poster Session V (ID 39) Poster

D-PO05-206 - The Impact Of Body Weight And Chronic Kidney Disease On The Development Of Atrial Fibrillation: A Nationwide Population Based Study (ID 1328)


Background: Body weight status and chronic kidney disease (CKD) are associated with development of new-onset atrial fibrillation (AF)
Objective: But, it is unclear whether there is any interaction between body mass index and glomerular filtration rate (GFR) also remains unclear. We performed this study to evaluate the role of underweight (body mass index [BMI] < 18.5), overweight (25.0 ≤ BMI < 30.0), obesity (BMI ≥ 30.0), and various stage of CKD on new-onset AF.
Methods: A total of 9,714,803 patients who underwent national health check-ups were analyzed. During 79,481,325 patient*years follow-up, a total of 193,241 new-onset AF occurred.
Results: Obese, overweight, and underweight patients showed significantly increased risk of new-onset AF compared to the normal reference group (18.5 ≤ BMI < 23.0). After multivariate adjustment, obese patients showed significantly higher risk for new-onset AF compared to the normal reference group (HR = 1.396; 95% CI = 1.363 - 1.430; p < 0.001; Figure1). CKD was classified into 3 stages according to GFR status.(GFR≥ 90 mL/min/1.73m2, 60≤ GFR <90, 60<GFR) and gradual escalation in the risk of new-onset AF was observed along with advancing diabetic stage (Figure1). Body weight and CKD were independently associated with new-onset AF and at the same time, had synergistic effects on the risk of new-onset AF with obese CKD patients having the highest risk.
Conclusion: Body weight status and diabetes were both independently associated with new-onset AF and had synergistic effects. The risk of new-onset AF increased gradually with advancing CKD stage. This study suggests that maintaining optimal body weight and preventing CKD might prevent new-onset AF.