Basic/Translational Science -> Whole Animal Electrophysiology and Pharmacology (includes Neurohumoral Modulation) D-BT01 - Cardiac Electrophysiology Society (CES): Lunch and Young Investigator Award Poster Session (ID 41) Special Session

D-BT01-08 - Potential Neural Mechanism Of Atrial Fibrillation Induced By Chronic Obstructive Sleep Apnea In Canine: Sympathetic Or Vagal? (ID 13)

Disclosure
 J. Xiaokereti: Nothing relevant to disclose.
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Abstract

Background: Obstructive sleep apnea (OSA) OSA plays a crucial role in the trigger and maintenance of atrial fibrillation (AF) through autonomic function rebalance, and chronic intermittent hypoxia is a major pathological mechanism of OSA.
Objective: We aim to find the potential mechanism of nerve activity and remodeling in chronic obstruction sleep apnea (OSA)dog model.
Methods: Eighteen dogs were randomly divided into a chronic OSA model group (n=10) and the control group (n=8). The blood gas analysis, atrial effective refractory period (AERP), and AF inducibility were detected since modeling started. After 12 weeks, the nerve distribution, function and activity of left vagal nerve (LVN) and left stellate ganglion(LSG)were measured. The chronic OSA model was established by repeatedly closing and reopening the airway for 12 weeks, four hours a day.
Results: With the process of modeling, the AERP and AF inducibility increased gradually compared with the control group (P <0.01). The nerve density of PGP9.5-positive, TH-positive neural in LSG were significantly increased compared with control group (P < 0.05). Furthermore, the mean value of frequency and amplitude of LSG neural activity were significantly increased, respectively (P < 0.05)
Conclusion: Chronic OSA improved autonomic remodeling by increasing the sympathetic and vagal nerve sprouting and activity. However, based on the neural activity recording during the spontaneous AF and nerve distribution in ICSN and LVN, the sympathetic nerve might be more related to the trigger and maintain the AF,which could be a potential mechanism besides the change of atrial structure and electrophysiology.$$graphic_{A3E0A2C0-C873-4ADA-82AA-237E94086D52}$$
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