Clinical Electrophysiology -> SVT/AVNRT/WPW/AT: -> Epidemiology of Cardiac Arrhythmias/ Epidemiology D-PO04 - Poster Session IV (ID 15) Poster

D-PO04-241 - Clinical Impact Of Polycythemia On Incident Atrial Fibrillation From The General Population (ID 1249)

Abstract

Background: Although adverse effect of anemia had been reported, effect of polycythemia on incident atrial fibrillation (AF) and cardiovascular outcome had not been revealed yet.
Objective: To investigate the clinical impact of polycythemia on incident atrial fibrillation from the general population.
Methods: We included 451,107 subjects who received national health examinations from the Korean National Health Insurance Service-based National Sample Cohort from 2009-2013. We divided male and female subjects into four categories each based on hemoglobin level (normal, moderate to severe and mild anemia, polycythemia) to assess each outcome.
Results: During1,735,964 person·years, 2,430 incident AF and 12,107 major adverse cardiovascular and cerebrovascular events (MACCE) were observed. Compared to normal hemoglobin range group, polycythemia group showed higher incident AF (HR=1.46[1.21-1.74] in male, HR=2.13 [1.03-4.77] in female), MACCE (HR=1.23 [1.12-1.35] in male, HR=1.79 [1.20-2.67] in female), incident MI (HR=1.37[1.05-1.79] in male, HR=3.46 [1.06-14.00] in female), and incident ischemic stroke (HR=1.27[1.10-1.46] in male, HR=1.72 [1.02-2.91] in female) (all p<0.001). Each outcome was linearly increased with the increase of hemoglobin among subjects with polycythemia (p<0.001), and with the decrease of hemoglobin among subjects with anemia (each p<0.001, U-shaped relationship). These relationshipswere more profound in obese female younger than 60-year-old.
Conclusion: Not only anemia but also polycythemia were significantly associated with higher rates of incident AF and MACCE among the general population.
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