Clinical Electrophysiology -> SVT/AVNRT/WPW/AT: -> Epidemiology of Cardiac Arrhythmias/ Epidemiology D-PO04 - Poster Session IV (ID 15) Poster

D-PO04-240 - Increased Risk Of Atrial Fibrillation In Patients With Atopic Triad: A Nationwide Population-based Study (ID 1248)

 Y. Choi: Nothing relevant to disclose.


Background: Atopic triad consists of asthma, allergic rhinitis, and atopic dermatitis which are linked by a shared mechanism of the immune system. The relationship between the atopic triad, multiple atopic conditions, and atrial fibrillation (AF) has not fully elucidated.
Objective: We sought to find whether the atopic triad is associated with incident AF.
Methods: A total of 6,748,564 subjects without a prevalent of AF (≥ 40-year-old, mean age 53.86 years) were identified from the National Health Insurance Services-Health Screening Cohort in 2009. Among these subjects, 1,168,196 (20.9%) patients had one or more active atopic diseases defined as those who have visited more than three times per year for asthma, allergic dermatitis, or atopic dermatitis.
Results: During 7.2 ± 1.0 years of follow-up, 136,253 subjects were newly diagnosed with AF (30,300 in the atopic group and 105,953 in the non-atopic group). The incidence rate (IR) of AF was 3.63 per 1000 person-year in the atopic group and 2.64 per 1000 person-year in the non-atopic group. After adjustment, the atopic group had a 25% higher risk of AF development compared to the non-atopic group. The risk of AF showed a dose-response association with the number of the atopic triad (hazard ratio, 95% confidence interval; one, 1.208, 1.192-1.225; two, 1.494, 1.452-1.537; and three, 1.551, 1.252-1.921) (Figure).
Conclusion: The atopic triad including asthma, allergic rhinitis, and atopic dermatitis was associated with an increased risk of AF. Multiple combinations of atopic diseases would have an impact on AF than non-atopic or one atopic disease. Cautious evaluation of AF would be needed in patients with multiple atopic diseases.