Clinical Electrophysiology -> SCA Risk Assessment: -> Other Noninvasive Techniques D-PO04 - Poster Session IV (ID 15) Poster

Abstract

Background: Cardiac sarcoidosis (CS) is associated with an increased risk of life-threatening arrhythmias and sudden cardiac death. Arrhythmia burden on 24 hour Holter monitoring has not been evaluated.
Objective: To describe the arrhythmia burden on 24 hour Holter in CS patients and to identify potential predictive factors for risk-stratification
Methods: Patients who met HRS Consensus Guideline criteria for CS and had at least one Holter monitor were identified from the Cardiac Sarcoidosis Consortium, a multicenter international registry of 428 patients with CS enrolled from 2011 to present. We analyzed the prevalence of the following arrhythmias on 24hr-Holter: non-sustained VT (NSVT), sustained VT, advanced AV block, and premature ventricular contraction (PVC) burden. Each arrhythmia was also stratified by sex and left ventricle ejection fraction (LVEF).
Results: Of 428 patients with definite CS, 164 (38.2%; male 62%, age 54.4±11.0 yrs) had at least one 24 hour Holter (total Holters 194, mean 1.2±0.6, range 1-5). NSVT (34.1%) and PVC≥5% (22.0%) were the most common findings (Figure). High burdens of PVCs were common: 15% had ≥10% PVCs and 6% had ≥20%. High degree AV block occurred in 5% and sustained VT in 4%. NSVT occurred significantly more in patients with reduced LVEF <50% (38/77 vs 15/78, p<0.001). Males had significantly higher burden of PVCs than females: ≥5% (28/103 vs. 8/61, p=0.0353); ≥10% (20/103 vs. 4/61, p=0.0243).
Conclusion: In this multicenter international registry, arrhythmias on Holter were common in CS patients with NSVT occurring in 1/3 of patients. NSVT occurred more frequently in patients with reduced LVEF and PVCs occurred more frequently in males.
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