Clinical Electrophysiology -> Atrial Fibrillation & Atrial Flutter: -> Physiology D-PO03 - Poster Session III (ID 48) Poster

D-PO03-226 - Systolic And Diastolic Blood Pressure Variability As Predisposing Factor For Atrial Fibrillation Recurrence In Hypertensive Patients (ID 1169)

 M. Kamioka: Nothing relevant to disclose.


Background: Although the blood pressure variability (BPV) is associated with cardiovascular mortality in hypertensive patients, there is no data about the effect of preprocedural BPV on pulmonary vein isolation (PVI) outcome in hypertensive atrial fibrillation (AF) patients.
Objective: To investigate the clinical impact of BPV on AF recurrence after PVI.
Methods: Fifty-seven hypertensive AF patients (51 male; mean age, 63 ± 7 years) who underwent successful PVI were enrolled and classified into the 2 groups: No-AF-Rec group (n = 39), no AF recurrence during the mean follow-up periods of 12 ± 6 months; and AF-Rec group (n = 18), the patient had AF recurrence. Systolic and diastolic BPV (Sys-BPV and Dia-BPV) were calculated as standard deviation. The study endpoint was AF recurrence, defined as AF documentation over 30 sec.
Results: Systolic BP and Sys-BPV in AF-Rec group were higher than those in No-AF-Rec group (139 ± 22 mmHg vs. 127 ± 16mmHg, P = 0.025; and 10.2 ± 3.4 vs. 7.8 ± 3.6, P = 0.021, respectively). There was no significant difference in diastolic BP and Dia-BPV between the 2 groups (P > 0.05). Cox multivariate regression analysis revealed that both Sys-BPV and Dia-BPV were the independent predictor of AF recurrence (Hazard ratio (HR): 1.125, P = 0.027; and HR 1.105, P = 0.045, respectively). Receiver-operating characteristic analysis revealed Sys-BPV of 9.4 and Dia-BPV as 6.5 as the cut-off value for AF recurrence. Kaplan-Meyer analysis showed that AF recurrence in high Sys-BPV and Dia-BPV was significantly higher than that in low Sys-BPV and Dia-BPV groups (Figure).
Conclusion: This study suggested that BPV is the useful predictor of AF recurrence in hypertensive AF patients.