Catheter Ablation -> Atrial Fibrillation & Atrial Flutter: -> Clinical Trials / Outcomes D-PO03 - Poster Session III (ID 48) Poster

D-PO03-197 - Atrial Fibrillation Ablation Leads To Left Ventricular Function Improvement Independent Of Rhythm (ID 1152)

Abstract

Background: Catheter ablation for atrial fibrillation (AF) patients with heart failure (HF) is an effective clinical therapy. However, its long-term effect on left ventricular ejection fraction (LVEF) patients is unclear.
Objective: To explore whether improvement in LVEF is sustained in patients receiving ablation.
Methods: We studied the change in LVEF in the CASTLE-AF patient population that received the AF ablation treatment. LVEF was assessed at each patient’s follow up visit using echocardiogram. During follow up, episodes of atrial arrhythmia recurrence were collected from the implantable defibrillators.
Results: A total of 153 patients, having a mean age of 61.5 ± 10.5 years, 88.9% male, were included in this subgroup analysis. Over a median follow-up of 3.82 years, 48 patients experienced AF recurrence at least once. The baseline mean LVEF of patients with and without recurrence was 32.8 ± 10.9 and 32.4 ± 8.5 (P= 0.82), respectively. Patients with AF recurrence were more likely to having persistent AF (38 (79.2%) vs 65 (61.9%), P=0.04). No significant difference was detected between mean LVEF before and after AF recurrence (41.66% (95% CI, 39.79 to 43.52) vs 41.59 (95% CI, 39.11-44.07), P=0.96) (Figure 1). The difference of delta LVEF before and after AF recurrence also reached no statistic difference (7.97 (95% CI, 6.11 to 9.84) vs 7.91 (95% CI, 5.42-10.39), P=0.96).
Conclusion: Among AF patients with heart failure, ablation can lead to sustained improvement of LVEF independent of recurrence of atrial arrhythmias.
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