Basic/Translational Science -> Computer Modeling/Simulation D-PO03 - Poster Session III (ID 48) Poster

D-PO03-017 - Pulmonary Vein Isolation Increases Efficacy Of Antiarrhythmic Drugs In A 3D Computer Model For Atrial Fibrillation (ID 1078)

Disclosure
 A. Gharaviri: Nothing relevant to disclose.

Abstract

Background: The success rate of antiarrhythmic drugs (AADs) and pulmonary vein isolation (PVI) in atrial fibrillation (AF) termination or recurrence significantly depends on the degrees of fibrosis induced by AF. Not all triggers initiating AF are located within the PVs as evidenced by AF recurrences in patients with proven PV isolation. Recent clinical study showed that the AADs and PVI have a synergy to reduce AF recurrences.
Objective: We hypothesized that the presence of AADs can suppress induction of AF by residual non-PV triggers.
Methods: We simulated the effect of fibrosis (FIB) on AF initiation likelihood in the presence of AADs, PVI, and PVI accompanied by AAD and in a highly detailed 3-dimensional model of the human atria with realistic electrophysiology and fibre orientations. The model geometry was based on MR images and histo-anatomical studies. AF was initiated in each simulation by a train of stimuli applied to 20 different pacing locations, outside of ablated area, in both atria. Two different AADs were simulated by either 60% reduction in INa conductivity (Na+-Block) or 30% reduction in IK1 conductivity (K+-Block).
Results: In simulations without PVI, an increase in the degree of FIB led to a significant efficacy loss of both Na+- and K+-Block in AF recurrence prevention. PVI, only reduced significantly AF recurrences in simulation with 0% and 50% of FIB but not in simulations with 70% FIB. The combination of AAD and PVI showed a significantly higher efficacy compare to PVI or AAD only simulations in simulations with 50% and 70% FIB.
Conclusion: In this simulation study, we showed that AADs, despite being ineffective before PVI, effectively suppress induction of AF after PVI.

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