Clinical Electrophysiology -> Atrial Fibrillation & Atrial Flutter: -> Physiology D-PO02 - Poster Session II (ID 47) Poster

D-PO02-236 - Non-genetic Risk Factors For Atrial Fibrillation Are Equally Important For Both Young And Old Population: A Nationwide Population-based Study (ID 1074)


Background: There are several non-genetic risk factors for new-onset atrial fibrillation (AF) such as age, sex, obesity, hypertension, diabetes, and alcohol consumption. However, whether these non-genetic risk factors have equal significance among different age groups is not known.
Objective: We performed this nationwide population based analysis to compare clinical significance of non-genetic risk factors for new-onset AF in various age groups.
Methods: A total of 9,797,409 people without a prior diagnosis of AF who underwent a national health check-up in 2009 were included. Impact of each risk factor on new-onset AF was examined in different age groups.
Results: Obesity, male sex, heavy alcohol consumption, smoking, hypertension, diabetes, and chronic kidney disease were associated with increased risk of new-onset AF. Although there were minor variations, these risk factors showed consistent association with the risk of new-onset AF among various age groups. With these risk factors, we created a scoring system to predict future risk of new-onset AF in different age groups. In receiver operating characteristic curve analysis, the predictive value of these risk factors ranged between 0.556 and 0.603 and no significant trend was observed.
Conclusion: Our study indicates non-genetic risk factors for new-onset AF have similar impact on different age groups. Except for sex status, these non-genetic risk factors are modifiable or partially modifiable. Therefore, efforts to control non-genetic risk factors can be important not only in old age people but also in young age people.