Catheter Ablation -> Atrial Fibrillation & Atrial Flutter: -> Ablation Techniques D-PO02 - Poster Session II (ID 47) Poster

D-PO02-135 - Immediate Post Ablation Drop And Slow Recovery Of Left Atrial Function After Left Atrial Ablation (ID 1025)


Background: The effect of ablation on left atrial (LA) mechanical function is unknown.
Objective: To quantify the immediate post-ablation drop and recovery in left atrial function using feature tracking in cardiac magnetic resonance imaging (MRI).
Methods: This study included atrial fibrillation (AF) patients that underwent radiofrequency catheter ablation (RFCA). All patients had at least 3 cardiac MRIs, one pre-ablation MRI, one immediate post-ablation MRI, and one or more follow-up MRI. The cardiac MRI included a cine-MRI during a complete cardiac cycle (RR interval). All cine-MR images were analyzed using a customized cardiac magnetic resonance feature tracking algorithm implemented in Matlab. The peak of the mean global longitudinal strains (GLS) for the atrial wall was recorded and analyzed for each MRI.
Results: A total of 21 patients (12 males, 9 females, age 67.0±8.7 years old) with AF that underwent RFCA were included. The pre-ablation MRIs were 15.3±11.9 days before ablation, and the immediate post-ablation MRIs were 1.5±2.0 days post-ablation. The pre-ablation GLS was significantly higher than the immediate post-ablation GLS (12.71±7.49 vs. 8.99±3.65; p=0.0227). After the immediate post-ablation drop, an increase in GLS was observed in all patients over a 3 months period and the GLS declined again over the course of a year.
Conclusion: There is a large and significant drop in left atrial function immediately post-ablation. LA function was restored within three months post-ablation followed by a continuous decline over the course of a year indicating that the underlying process of structural remodeling continued in these patients.