Catheter Ablation -> Atrial Fibrillation & Atrial Flutter: -> Ablation Techniques D-PO02 - Poster Session II (ID 47) Poster

Abstract

Background: Radiofrequency catheter ablation, a widely recognized therapeutic option for atrial fibrillation (AF) has limited success rate as it is influenced by several factors.
Objective: To evaluate the ablation success in AF patients intervened early versus late in the disease course.
Methods: Consecutive AF patients undergoing their first catheter ablation in 2015-16 at our center were included in the analysis. Patients were classified into two groups based on the time to ablation after AF diagnosis; 1) early: ≤12 months and 2) late: >12 months. All received PV isolation (PVI) plus isolation of posterior wall (PW) and superior vena cava (SVC). Additionally, in non-paroxysmal AF cases, non-PV triggers were identified with isoproterenol-challenge and ablated. Patients were prospectively followed up for 3 years with regular rhythm monitoring.
Results: A total of 752 and 1248 patients were included in the ‘early’ and ‘late’ group respectively. Baseline characteristics of the study population is provided in Table 1 A. At 3 years of follow-up, overall success rate off-antiarrhythmic drugs was significantly higher in the ‘early’ group (66.3% vs 58.6%, p<0.001). After stratification by AF type, ‘early’ group was still associated with significantly higher success rate compared to the ‘late’ group (Table 1 B).
Conclusion: In this large series with standardized ablation strategy, early intervention with catheter ablation was associated with higher success rate in all AF types.
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